Brittain Thomas
School of Biological Sciences, The University of Auckland, Auckland, New Zealand.
Mol Aspects Med. 2002 Aug;23(4):293-342. doi: 10.1016/s0098-2997(02)00004-3.
In order to provide the appropriate level of oxygen transport to respiring tissues, we need to produce a molecular oxygen transporting system to supplement oxygen diffusion and solubility. This supplementation is provided by hemoglobin. The role of hemoglobin in providing oxygen transport from lung to tissues in the adult is well-documented and functional characteristics of the fetal hemoglobin, which provide placental oxygen exchange, are also well understood. However the characteristics of the three embryonic hemoglobins, which provide oxygen transport during the first three months of gestation, are not well recognized. This review seeks to describe the state of our understanding of the temporal control of the expression of these proteins and the oxygen binding characteristics of the individual protein molecules. The modulation of the oxygen binding properties of these proteins, by the various allosteric effectors, is described and the structural origins of these characteristics are probed.
为了向呼吸组织提供适当水平的氧气运输，我们需要构建一个分子氧运输系统来补充氧气扩散和溶解性。这种补充由血红蛋白提供。血红蛋白在成体中将氧气从肺部运输到组织中的作用已有充分记载，而胎儿血红蛋白在胎盘氧交换中的功能特性也已为人熟知。然而，在妊娠前三个月提供氧气运输的三种胚胎血红蛋白的特性尚未得到充分认识。本综述旨在描述我们对这些蛋白质表达的时间控制以及各个蛋白质分子的氧结合特性的理解现状。文中描述了各种别构效应剂对这些蛋白质氧结合特性的调节，并探究了这些特性的结构起源。
