Sharma Vinay, Allgar Victoria, Rajkhowa M
Assisted Conception Unit, St James's University Hospital, Leeds, United Kingdom.
Fertil Steril. 2002 Jul;78(1):40-6. doi: 10.1016/s0015-0282(02)03160-6.
To examine the cumulative conception rate and live birth rate in women undergoing IVF and to assess the influence of prognostic factors on cumulative conception rate and discontinuation of treatment.
Retrospective analysis of data from couples undergoing IVF.
Assisted conception unit of a university hospital.
PATIENT(S): Two thousand fifty-six patients undergoing 2708 cycles of IVF from April 1992 to March 1999.
MAIN OUTCOME MEASURE(S): Cumulative conception rate by age, number of oocytes retrieved, and embryos transferred, and the influence of these factors on dropout rates.
RESULT(S): The cumulative conception rate and cumulative live birth rate after four attempts were 75% and 66%, respectively. The cumulative conception rate differed significantly between women 35 years of age or younger and those older than 35 years who had five or more oocytes retrieved (83% vs. 63%). When fewer than five oocytes were retrieved in women 35 years of age or younger, the cumulative conception rate decreased to 33%. Overall, 36% of patients continued treatment after the first attempt; these patients were more likely to have more than five oocytes retrieved and more than two embryos available for transfer.
The cumulative conception rate was greater when the female partner was 35 years of age or younger and had more than five oocytes retrieved and more than two embryos were available for transfer. These factors influenced dropout rates.
研究接受体外受精（IVF）的女性的累积受孕率和活产率，并评估预后因素对累积受孕率和治疗中断的影响。
对接受IVF的夫妇的数据进行回顾性分析。
一家大学医院的辅助生殖科。
1992年4月至1999年3月期间接受2708个IVF周期治疗的2056例患者。
按年龄、取卵数和移植胚胎数计算的累积受孕率，以及这些因素对退出率的影响。
四次尝试后的累积受孕率和累积活产率分别为75%和66%。35岁及以下且取卵数为五个或更多的女性与35岁以上且取卵数为五个或更多的女性的累积受孕率有显著差异（83%对63%）。35岁及以下女性取卵数少于五个时，累积受孕率降至33%。总体而言，36%的患者在首次尝试后继续治疗；这些患者更有可能取卵数超过五个且有两个以上胚胎可供移植。
女性伴侣年龄在35岁及以下、取卵数超过五个且有两个以上胚胎可供移植时，累积受孕率更高。这些因素影响退出率。
