Zak M, Rezný Z, Dienstbier Z, Uhlírová A
Strahlentherapie. 1975 Dec;150(6):578-84.
The paper presented deals with the statistical utilization of changes in lymphocyte and hypersegmented neutrophiles counts in peripheral blood after irradiation for the biological detection of ionizing radiation. Both followed-up parameters are in a good correlation during simultaneous evaluation of their changes, and they fail during evaluation in various time intervals after irradiation. The changes of two hematological parameters after irradiation, lymphopenia and hypersegmentation of cellular nuclei of granulocytes were therefore utilized. The changes under examination were elaborated in the computer and avaluated by method of regression classification and by discriminatory analysis. This analytical way enables a new conception during the evaluation of individual hematological post-irradiation changes. This study is being continued in several lines. On the one hand, further statistical methods of making the results more precise will be used, on the other hand, other laboratory animals will be tested as well. Last but not least, the best statistical method will be used in an attempt to detect biologically the changes after the therapeutical irradiation in man.
本文介绍了利用外周血中淋巴细胞和多分叶嗜中性粒细胞计数的变化进行统计学分析，以实现对电离辐射的生物检测。在同时评估这两个后续参数的变化时，它们具有良好的相关性，但在照射后的不同时间间隔进行评估时，它们的相关性则不明显。因此，研究利用了照射后两个血液学参数的变化，即淋巴细胞减少和粒细胞细胞核多分叶。通过计算机对所研究的变化进行了详细分析，并采用回归分类法和判别分析法进行评估。这种分析方法为评估个体照射后的血液学变化提供了一个新的概念。本研究正在从几个方面继续进行。一方面，将使用更精确的统计方法，另一方面，也将对其他实验动物进行测试。最后但同样重要的是，将使用最佳统计方法来尝试从生物学角度检测人类治疗性照射后的变化。
