Nuclear lipid metabolism and signaling.

Evidence has been accumulating that nuclear lipid metabolism is involved in the regulation of nuclear functions. Here I describe an autonomous nuclear lipid signaling that has been found to be associated with the metabolism of such lipids as phosphoinositides, choline phospholipids, and the acylation and deacylation cycle. Some lipid signals from the plasma membrane ultimately reach the nucleus and regulate the nuclear function. In this case, however, generated lipids and their metabolites may not directly act on the nuclear factors involved in nuclear function. The unique and direct effects of nuclear lipids and their metabolites on nuclear factors are also discussed.