Worman Howard J
Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, 10th Floor, Room 508, New York, NY 10032, USA.
Biochim Biophys Acta. 2006 May-Jun;1761(5-6):626-31. doi: 10.1016/j.bbalip.2006.02.010. Epub 2006 Mar 20.
Smads mediate signal transduction by cytokines of the transforming growth factor-beta family. Recent data show that intrinsic and extrinsic proteins of the inner nuclear membrane affect the activities of Smads. MAN1, an integral protein of the inner nuclear membrane, binds to receptor-regulated Smads and antagonizes signaling by transforming growth factor-beta, activin and bone morphogenic protein. Lamins A and C, extrinsic intermediate filament proteins of the inner nuclear membrane that are mutated in several human diseases, appear to regulate phosphorylation of Smads. These data demonstrate that proteins within and associated with the inner nuclear membrane lipid bilayer regulate signal transduction pathways involved in numerous developmental, physiological and pathophysiological processes.
Smads介导转化生长因子-β家族细胞因子的信号转导。最近的数据表明，内核膜的内在和外在蛋白会影响Smads的活性。MAN1是内核膜的一种整合蛋白，它与受体调节型Smads结合，并拮抗转化生长因子-β、激活素和骨形态发生蛋白的信号传导。核纤层蛋白A和C是内核膜的外在中间丝蛋白，在几种人类疾病中发生突变，似乎能调节Smads的磷酸化。这些数据表明，内核膜脂质双层内及其相关的蛋白调节着涉及众多发育、生理和病理生理过程的信号转导途径。
