孕产妇牙周病与早产低体重：病例对照研究。

Maternal periodontal disease and preterm low birthweight: case-control study.

作者信息

Davenport E S, Williams C E C S, Sterne J A C, Murad S, Sivapathasundram V, Curtis M A

机构信息

Department of Oral Growth and Development, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, Turner Street, London E1 2AD, UK.

出版信息

J Dent Res. 2002 May;81(5):313-8. doi: 10.1177/154405910208100505.

DOI:10.1177/154405910208100505

PMID:12097443

Abstract

Periodontal disease has been suggested to be an important risk factor for preterm low birthweight (PLBW). Here we report a case-control study of 236 cases (infants < 37 wks and weighing < 2499 g) and a daily random sample of 507 controls (> or = 38 wks and weighing > or = 2500 g). Clinical periodontal indices were measured on the labor wards. Associated risk factors for periodontal disease and PLBW were ascertained by means of a structured questionnaire and maternity notes. The risk for PLBW decreased with increasing pocket depth (odds ratio [OR] 0.83, 95% confidence interval [CI] 0.68 to 1.00). After adjustment for maternal age, ethnicity, maternal education, smoking, alcohol consumption, infections, and hypertension during pregnancy, this decreased further (OR 0.78, 95% CI 0.64 to 0.99). We found no evidence for an association between PLBW and periodontal disease. Our results do not support a specific drive to improve periodontal health of pregnant women as a means of improving pregnancy outcomes.

摘要

牙周疾病被认为是早产低体重（PLBW）的一个重要风险因素。在此我们报告一项病例对照研究，该研究涉及236例病例（孕周小于37周且体重小于2499克的婴儿）以及507名对照的每日随机样本（孕周大于或等于38周且体重大于或等于2500克）。在产房测量临床牙周指数。通过结构化问卷和产妇病历确定牙周疾病和早产低体重的相关风险因素。早产低体重的风险随着牙周袋深度增加而降低（优势比[OR]0.83，95%置信区间[CI]0.68至1.00）。在对孕妇年龄、种族、受教育程度、吸烟、饮酒、感染及孕期高血压进行校正后，该风险进一步降低（OR 0.78，95%CI 0.64至0.99）。我们未发现早产低体重与牙周疾病之间存在关联的证据。我们的结果不支持将改善孕妇牙周健康作为改善妊娠结局的一种特定举措。