Kim Sam K, Miller John H
Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles 90039-1812, USA.
J Nucl Med. 2002 Jul;43(7):896-900.
Over a period of 11 y, 50 patients (22 males, 28 females; age range, 8 mo to 22 y) presenting with sickle cell-associated bone pain underwent 93 sequential examinations with 99mTc-sulfur colloid bone marrow scanning and 99mTc-diphosphonate bone scanning. Multiple examinations were performed on 21 patients. The number and distribution of total acute, healed, and nonhealed infarcts by location were recorded on a skeletal homunculus.
For this population, the total number of sites of bone and bone marrow infarction was 464. Of these, 175 were classified as acute by clinical and scintigraphic findings. There were a total of 61 nonhealed sites and 162 healed sites.
Knowledge of the distribution and natural history of sites of bone and bone marrow infarction is of considerable clinical and diagnostic import in the ongoing evaluation and treatment of sickle hemoglobinopathies.
在11年的时间里，50例（22例男性，28例女性；年龄范围8个月至22岁）患有镰状细胞相关骨痛的患者接受了93次连续检查，包括99mTc-硫胶体骨髓扫描和99mTc-二膦酸盐骨扫描。21例患者进行了多次检查。通过在骨骼模型上记录按部位划分的急性、愈合和未愈合梗死灶的总数及分布情况。
对于该人群，骨和骨髓梗死部位总数为464个。其中，根据临床和闪烁扫描结果，175个被分类为急性梗死灶。共有61个未愈合部位和162个愈合部位。
了解骨和骨髓梗死部位的分布及自然病史对于镰状血红蛋白病的持续评估和治疗具有重要的临床和诊断意义。
