gp130在大脑皮质发育中的作用：小鼠体外系统中的体内功能分析
The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system.
作者信息
Hatta Toshihisa, Moriyama Kenji, Nakashima Kinichi, Taga Tetsuya, Otani Hiroki
机构信息
Department of Anatomy, Shimane Medical University, Izumo 693-8501, Japan.
出版信息
J Neurosci. 2002 Jul 1;22(13):5516-24. doi: 10.1523/JNEUROSCI.22-13-05516.2002.
Abstract
The role of gp130 in cerebral cortical histogenesis remains unknown. Mice lacking gp130 showed a hypoplastic cortical plate and decreased incorporation of 5-bromo-2'-deoxyuridine (BrdU) in progenitor cells of the developing cerebrum. In contrast, injection of leukemia inhibitory factor (LIF), a gp130 ligand, into the lateral cerebral ventricle of wild-type embryos exo utero induced hyperplasia of the cerebral cortex and increased the incorporation of BrdU in progenitor cells. Furthermore, chronologically controlled injection of LIF followed or preceded by BrdU revealed that gp130-mediated signals promote the progenitor cells to reenter the stem cell cycle without affecting the duration of cell cycle and enhance the migration of postmitotic neurons in the developing cerebrum.
摘要
gp130在大脑皮质组织发生中的作用尚不清楚。缺乏gp130的小鼠表现出皮质板发育不全，且发育中的大脑祖细胞中5-溴-2'-脱氧尿苷（BrdU）的掺入减少。相比之下，向野生型胚胎子宫外的侧脑室注射白血病抑制因子（LIF，一种gp130配体）可诱导大脑皮质增生，并增加祖细胞中BrdU的掺入。此外，按时间顺序控制LIF注射，在BrdU注射之前或之后进行，结果显示gp130介导的信号可促进祖细胞重新进入干细胞周期，而不影响细胞周期的持续时间，并增强发育中大脑有丝分裂后神经元的迁移。
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