[Effect of ischemia on content of acid-soluble nucleotides in rat liver].

A drop in the acid-soluble nucleotide concentrations was studied in the rat liver following different periods of ishemia as well as the resynthesis of these compounds 2 and 24 h after re-establishment of blood circulation. After 5 min ishemia sharp drop was found in the amount of nucleoside triphosphates, UDP-glucose and UDP-glucuronic acid. After 30 to 60 min ischemia the available quantities of acid-soluble nucleotides remained unchanged, then a tendency to a subsequent slight reduction in their amount was observed. All acid-soluble nucleotides the quantity of which dropped noticeably during ischemia were resynthesized to a great extent 2 hours after re-establishment of blood circulation in 30- and 60-min ischemic livers; the synthesizing ability of the 120-min ischemic liver cells was considerably weaker than that of 30 and 60-min ischemic cells, particularly in the later periods after cessation of ischemia.