用于腹侧和切口疝修补的人工合成补片的组织附着强度。在新西兰白兔粘连模型中的一项研究。
Tissue attachment strength of prosthetic meshes used in ventral and incisional hernia repair. A study in the New Zealand White rabbit adhesion model.
作者信息
LeBlanc K A, Bellanger D, Rhynes K V, Baker D G, Stout R W
机构信息
Surgical Specialty Group, Medical Plaza, Suite 612, 7777 Hennessy Boulevard, Suite 612, Baton Rouge, LA 70808, USA.
出版信息
Surg Endosc. 2002 Nov;16(11):1542-6. doi: 10.1007/s00464-001-8271-y. Epub 2002 Jul 8.
BACKGROUND
Many prosthetic materials are used in incisional hernia repair, including polypropylene (PP) and expanded polytetrafluoroethylene (ePTFE). However, PP forms severe adhesions and ePTFE has raised concerns about the adequacy of tissue attachment.
METHODS
The early tissue attachment strength of PP and two new forms of ePTFE (DLM and DLMC) was compared in a rabbit model (n = 12) in which disks of the three meshes (n = 8 of each material) were implanted against the abdominal wall for 3 days.
RESULTS
Tensiometer testing found that DLMC mesh had significantly greater attachment strength than PP (p = 0.02). Histologic studies indicated that this was due to cellular ingrowth. Tissue adhesions were observed with all eight PP disks, one DLMC disk, and none of the DLM disks.
CONCLUSION
Modified forms of ePTFE mesh may provide abdominal wall repairs that are as strong or stronger than those obtained with PP, with early tissue attachment and without adhesions.
背景
许多假体材料用于切口疝修补，包括聚丙烯（PP）和膨化聚四氟乙烯（ePTFE）。然而，PP会形成严重粘连，ePTFE则引发了对组织附着充分性的担忧。
方法
在兔模型（n = 12）中比较PP和两种新型ePTFE（DLM和DLMC）的早期组织附着强度，将三种补片（每种材料n = 8）的圆盘贴腹壁植入3天。
结果
张力计测试发现，DLMC补片的附着强度显著高于PP（p = 0.02）。组织学研究表明，这是由于细胞向内生长所致。所有8个PP圆盘和1个DLMC圆盘均观察到组织粘连，而DLM圆盘均未观察到粘连。
结论
改良形式的ePTFE补片可为腹壁修补提供与PP修补同样牢固或更牢固的效果，具有早期组织附着且无粘连。
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