通过双重施蒂勒反应合成对称类胡萝卜素。
Synthesis of symmetrical carotenoids by a two-fold Stille reaction.
作者信息
Vaz Belén, Alvarez Rosana, de Lera Angel R
机构信息
Departamento de Química Orgánica, Facultad de Ciencias, Universidade de Vigo. 36200 Vigo, Spain.
出版信息
J Org Chem. 2002 Jul 12;67(14):5040-3. doi: 10.1021/jo025727f.
PMID:12098335
Abstract
beta-Carotene 1 and (3R,3'R)-zeaxanthin 2 have been stereoselectively prepared in a highly convergent fashion by a 2-fold Stille cross-coupling reaction. The C(12)-pentaenylbis-stannane 8 is the central "lynchpin" that connects two units of the terminal C(14)-iodides 9 and 17 to afford 1 and 2, respectively.
摘要
β-胡萝卜素1和（3R，3′R）-玉米黄质2已通过两步Stille交叉偶联反应以高度汇聚的方式立体选择性合成。C（12）-戊烯基双锡烷8是连接两个末端C（14）-碘化物9和17单元的中心“关键中间体”，分别得到1和2。
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