Saab C Y, Garcia-Nicas E, Willis W D
Department of Anatomy and Neurosciences, University of Texas Medical Branch, MBI, 301 University Boulevard, Galveston, TX 77555-1069, USA.
Neurosci Lett. 2002 Jul 12;327(1):17-20. doi: 10.1016/s0304-3940(02)00379-8.
The cerebellum was recently proposed to play a role in cognition and sensation in addition to motor phenomena. We have shown that the cerebellum is involved in the processing of sensory nociceptive information. In this study, the activity of neurons in the dorsal column nuclei (DCN) was tested following stimulation in the rat fastigial nucleus. The results showed an enhancement of the extracellularly recorded responses of DCN neurons to somatic non-noxious stimuli following injection of D,L-homocysteic acid (0.1 M, 1 microl) into the area of the fastigial nucleus. We conclude that the cerebellum influences the processing of non-noxious somatosensory information at the level of the DCN, an important relay and a center for the processing of fine tactile and vibratory information. This observation is not yet supported by clinical data.
最近有人提出，小脑除了在运动现象中起作用外，还在认知和感觉方面发挥作用。我们已经表明，小脑参与感觉伤害性信息的处理。在本研究中，在大鼠顶核受到刺激后，对其薄束核（DCN）中神经元的活动进行了测试。结果显示，在向顶核区域注射D，L-高半胱氨酸（0.1M，1微升）后，细胞外记录到的DCN神经元对躯体非伤害性刺激的反应增强。我们得出结论，小脑在DCN水平上影响非伤害性躯体感觉信息的处理，DCN是精细触觉和振动信息处理的重要中继站和中心。这一观察结果尚未得到临床数据的支持。
