Saakyan S G, Kazaryan A K, Grigoryan G Yu, Minasyan S M, Sarkisyan R Sh
Department of Human and Animal Physiology, Erevan State University, Armenia.
Neurosci Behav Physiol. 2006 Jun;36(5):553-9. doi: 10.1007/s11055-006-0055-3.
Acute experiments on Nembutal-anesthetized (40 mg/kg, i.p.) white rats with extracellular recording and analysis of baseline spine activity of neurons in the fastigial nucleus of the cerebellum were performed in normal conditions and after exposure to vibration for 5, 10, and 15 days. The distribution of neurons in terms of the regularity and dynamics of spike flows and the modality of interspike interval histograms were determined, along with the mean neuron spike frequency and the coefficient of variation of interspike intervals. The results showed that the most significant changes in neuron activity in fastigial nucleus cells were formed during the first ten days of vibration. On day 15, there was a tendency for measures to return to control levels.
在正常条件下以及暴露于振动5天、10天和15天后，对戊巴比妥麻醉（腹腔注射40mg/kg）的白色大鼠进行急性实验，采用细胞外记录并分析小脑顶核神经元的基线棘突活动。确定了神经元在放电序列的规律性和动态性以及峰峰间期直方图模式方面的分布情况，同时还测定了神经元的平均放电频率和峰峰间期的变异系数。结果表明，小脑顶核细胞神经元活动的最显著变化在振动的前十天形成。在第15天，各项指标有恢复到对照水平的趋势。
