Hirschl M, Katzenschlager R, Ammer K, Melnizky P, Rathkolb O, Kundi M
Angiologische Ambulanz und Tagesklinik, Hanuschkrankenhaus Wien.
Vasa. 2002 May;31(2):91-4. doi: 10.1024/0301-1526.31.2.91.
No causal treatment of primary Raynaud's phenomenon is available due to its unclear aetiology. Low level laser therapy (LLLT) is applied in a multitude of medical conditions often without sufficient evidence of efficacy and established mechanisms. To asses the effect of this therapy in patients with primary Raynaud's phenomenon a randomised, double blind, placebo controlled cross over study was designed.
Absolute and relative frequency and intensity of vasospastic attacks during three weeks of either LLLT or placebo therapy and results of infrared thermography before onset and at the end of both therapy sequences were evaluated in 15 patients with primary Raynaud's phenomenon.
Frequency of Raynaud's attacks was not significantly affected by low level laser therapy. Compared to placebo a significantly lower intensity of attacks during laser irradiation was observed, but no transfer effect occurred. Additionally the mean temperature gradient after cold exposure was reduced after laser irradiation, while the number of fingers showing prolonged rewarming was unaffected.
Though further studies are necessary to confirm these results we could demonstrate for the first time in a double blind placebo controlled clinical trial that low laser therapy is a potential candidate for an effective therapy of Raynaud's phenomenon, although effects seem to be of short duration.
原发性雷诺现象病因不明，尚无因果性治疗方法。低强度激光疗法（LLLT）常用于多种医学病症，但其疗效及作用机制往往缺乏充分证据。为评估该疗法对原发性雷诺现象患者的疗效，设计了一项随机、双盲、安慰剂对照的交叉研究。
对15例原发性雷诺现象患者，评估了低强度激光疗法或安慰剂疗法三周内血管痉挛发作的绝对和相对频率及强度，以及两个治疗阶段开始前和结束时的红外热成像结果。
低强度激光疗法对雷诺发作频率无显著影响。与安慰剂相比，激光照射期间发作强度显著降低，但未出现转移效应。此外，激光照射后冷暴露后的平均温度梯度降低，而手指复温延长的数量未受影响。
尽管需要进一步研究来证实这些结果，但我们首次在双盲安慰剂对照临床试验中证明，低强度激光疗法可能是雷诺现象有效治疗的潜在选择，尽管其效果似乎持续时间较短。
