Whitmore S E, Wigley F M, Wise R A
Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
J Rheumatol. 1995 Jan;22(1):50-4.
Raynaud's phenomenon is a relatively common disorder for which highly effective, well tolerated treatment has yet to be developed. Minoxidil, a potent vasodilator which, on a single application to the scalp causes significant local cutaneous vasodilation, was selected for study in primary Raynaud's phenomenon.
Ten subjects were enrolled in a randomized double blind, placebo controlled acute challenge crossover trial. Single applications of topical minoxidil 5% solution and placebo were made to each subject's fingers on 2 separate occasions, and measures of digital skin temperature, systolic blood pressure, and laser Doppler flow were obtained, before and after acute cold challenge.
Digital skin temperature, systolic blood pressure, and laser Doppler flow both before and after cold challenge were not improved by pretreatment with topical minoxidil 5% solution.
In individuals with primary Raynaud's phenomenon, a single application of minoxidil 5% solution to the fingers is not effective in improving baseline digital blood flow or cold tolerance.
雷诺现象是一种相对常见的疾病，目前尚未开发出高效且耐受性良好的治疗方法。米诺地尔是一种强效血管扩张剂，单次应用于头皮可引起显著的局部皮肤血管扩张，本研究选用米诺地尔治疗原发性雷诺现象。
10名受试者参与了一项随机双盲、安慰剂对照的急性激发交叉试验。在2个不同的场合，分别对每位受试者的手指单次涂抹5%米诺地尔溶液和安慰剂，并在急性冷激发前后测量手指皮肤温度、收缩压和激光多普勒血流。
5%米诺地尔溶液预处理后，冷激发前后的手指皮肤温度、收缩压和激光多普勒血流均未得到改善。
对于原发性雷诺现象患者，手指单次涂抹5%米诺地尔溶液对改善基线手指血流或耐寒性无效。
