Van De Bor Véronique, Giangrande Angela
Institut de Génétique et Biologie Moléculaire et Cellulaire, IGBMC/CNRS/ULP/INSERM - BP 163 67404 ILLKIRCH, c.u. de Strasbourg, France.
Curr Opin Genet Dev. 2002 Aug;12(4):465-72. doi: 10.1016/s0959-437x(02)00327-1.
Neurons and glia are generated by multipotent precursors. Recent studies indicate that the choice between the two fates depends on the combined activity of extracellular influences and factors that respond to precise spatial and temporal cues. Drosophila provides a simple genetic model to study the cellular and molecular mechanisms controlling fate choice, mode of precursor division and generation of cell diversity. Moreover, all glial precursors and glial-promoting activities have been identified in Drosophila, which provides us with a unique opportunity to dissect regulatory pathways controlling glial differentiation and specification.
神经元和神经胶质细胞由多能前体细胞产生。最近的研究表明，这两种细胞命运的选择取决于细胞外影响因素以及对精确时空线索作出反应的因子的综合作用。果蝇提供了一个简单的遗传模型，用于研究控制命运选择、前体细胞分裂模式以及细胞多样性产生的细胞和分子机制。此外，果蝇中所有的神经胶质前体细胞和促进神经胶质细胞生成的活性物质都已被鉴定出来，这为我们提供了一个独特的机会来剖析控制神经胶质细胞分化和特化的调控途径。
