Bernardoni R, Vivancos V, Giangrande A
Institut de Génétique et Biologie Moléculaire et Cellulaire, IGBMC/CNRS/ULP, BP 163 67404 Illkirch, c.u. de Strasbourg, France.
Dev Biol. 1997 Nov 1;191(1):118-30. doi: 10.1006/dbio.1997.8702.
Glial cell differentiation in Drosophila melanogaster requires the activity of glide/gcm (glial cell deficient/glial cell missing). The role of this gene is to direct the cell fate switch between neurons and glial cells by activating the glial developmental program in multipotent precursor cells of the nervous system. In this paper, we show that glide/gcm is also expressed and required in the lineage of hemocytes/macrophages, scavenger cells that phagocytose cells undergoing programmed cell death. In addition, we show that, as for glial cells, glide/gcm plays an instructive role in hemocyte differentiation. Interestingly, it has been shown that in the development of the fly adult nervous system the role of scavenger cells is played by glial cells. These data and our findings on the dual role of glide/gcm indicate that glial cells and hemocytes/macrophages are functionally and molecularly related.
果蝇中的神经胶质细胞分化需要glide/gcm（神经胶质细胞缺陷/神经胶质细胞缺失）的活性。该基因的作用是通过激活神经系统多能前体细胞中的神经胶质发育程序，来引导神经元和神经胶质细胞之间的细胞命运转换。在本文中，我们表明glide/gcm在血细胞/巨噬细胞谱系中也有表达且是必需的，血细胞/巨噬细胞是吞噬经历程序性细胞死亡的细胞的清道夫细胞。此外，我们表明，与神经胶质细胞一样，glide/gcm在血细胞分化中起指导作用。有趣的是，已经表明在果蝇成虫神经系统的发育中，清道夫细胞的作用由神经胶质细胞承担。这些数据以及我们关于glide/gcm双重作用的发现表明，神经胶质细胞和血细胞/巨噬细胞在功能和分子层面上是相关的。
