Pinderski Laura J, Fonarow Gregg C, Hamilton Michele, Fishbein Michael C, Marelli Daniel, Moriguchi Jaime, Cohen Benjamin, Kobashigawa Jon A
Division of Cardiology, UCLA Medical Center, Los Angeles, California, USA.
J Heart Lung Transplant. 2002 Jul;21(7):818-21. doi: 10.1016/s1053-2498(01)00396-5.
We describe a case of a 40-year-old man who presented with recent-onset, rapidly decompensating heart failure, and who was found to have giant cell myocarditis (GCM) on biopsy. The patient responded to myocardial rest on a biventricular assist device, as well as immunosuppression that included eradication of T cells using OKT3 therapy, coupled with high-dose steroids. The patient was successfully weaned off mechanical support, and ultimately discharged home, where he continues to do well. Based on a review of the clinical and experimental literature, we believe treatment with T-lymphocytic cytolytic therapy may be beneficial. Further studies using this therapy in the treatment of GCM are warranted.
我们描述了一例40岁男性患者，该患者近期出现快速失代偿性心力衰竭，活检发现患有巨细胞性心肌炎（GCM）。患者在双心室辅助装置上进行心肌休息治疗，并接受免疫抑制治疗，包括使用OKT3疗法清除T细胞，同时联合大剂量类固醇。患者成功撤掉机械支持，最终出院回家，目前情况良好。基于对临床和实验文献的回顾，我们认为T淋巴细胞溶解疗法可能有益。有必要进一步开展使用该疗法治疗GCM的研究。
