Deininger Martin H, Kremsner Peter G, Meyermann Richard, Schluesener Hermann
Institute of Brain Research, University of Tuebingen Medical School, Calwer Str. 3, D-72076 Tuebingen, Germany.
Eur Cytokine Netw. 2002 Apr-Jun;13(2):173-85.
Cerebral malaria is a life threatening sequel of Plasmodium falciparum infection and contributes significantly to malaria mortality, especially among children. Accumulation of macrophages and proliferation of microglial cells play key roles in cerebral malaria and are thought to contribute to the pathophysiological alterations observed in these patients, which include enhanced adherence of infected erythrocytes to the cerebral vasculature by expression and secretion of proinflammatory molecules, disruption of the blood-brain barrier, recruitment of other inflammatory cells to the lesion site. In this review, recent advances in the understanding of the involvement of macrophages/microglial cells in the development of cerebral malaria are summarized.
脑型疟疾是恶性疟原虫感染的一种危及生命的后遗症，对疟疾死亡率有显著影响，尤其是在儿童中。巨噬细胞的积聚和小胶质细胞的增殖在脑型疟疾中起关键作用，被认为是导致这些患者出现病理生理改变的原因，这些改变包括感染的红细胞通过促炎分子的表达和分泌增强对脑血管的黏附、血脑屏障的破坏以及其他炎症细胞向病变部位的募集。在这篇综述中，总结了对巨噬细胞/小胶质细胞参与脑型疟疾发展的最新认识进展。
