Leksin E N
Vopr Neirokhir. 1975 Nov-Dec(6):31-4.
The results of investigations (roentgenological, isotopic, CSL-dynamics) made in 377 patients are reported. It has been ascertained that at the root of pathogenesis of intracranial pressure disturbances consequent upon cerebro-cranial traumas lie pathological changes in the ependyma and meninges, which lead to derangements of the hemo- and CSF-dynamics. At least four mechanisms particpate in their pathogenesis, viz 1) reduced resorptive capacity of the meninges; 2) partical occlusion on the routes of the CSF outflow; 3) dilatation of intracranial and diploic veins; 4) increased permeability of the blood-brain barrier.
报告了对377例患者进行的调查(X线、同位素、脑脊液动力学)结果。已确定,颅脑创伤后颅内压紊乱的发病机制根源在于室管膜和脑膜的病理变化,这会导致血液和脑脊液动力学紊乱。其发病机制至少有四种机制参与,即:1)脑膜吸收能力降低;2)脑脊液流出途径部分阻塞;3)颅内和板障静脉扩张;4)血脑屏障通透性增加。