醋酸试验：一种用于早期检测宫颈癌的有前景的筛查试验。

Acetic acid test: a promising screening test for early detection of cervical cancer.

作者信息

Rodríguez-Reyes Esperanza Rosalba, Cerda-Flores Ricardo M, Quiñónez-Pérez Juan Manuel, Velásco-Rodríguez Víctor, Cortés-Gutiérrez Elva I

机构信息

Department of Gynecology, Hospital General de Zona 46, Instituto Mexicano del Seguro Social, Gómez Palacio, Durango.

出版信息

Anal Quant Cytol Histol. 2002 Jun;24(3):134-6.

PMID:12102124

Abstract

OBJECTIVE

To determine whether the acetic acid test (AAT) could be used as a screening testfor early detection of cervical cancer.

STUDY DESIGN

A hospital-based study was carried out. A sample of 376 women who attended the early cancer detection program of the Instituto Mexicano del Seguro Social in the state of Durango during 1998 was included. The AAT was applied during the gynecologic examination. Each women underwent colposcopy and directed cervical biopsy.

RESULTS

The biopsies revealed that five women had cervical intraepithelial neoplasia grade 1 (CIN 1) and 51, 2/3. Four values (true positive,false positive, false negative and true negative) were obtained according to the pathologic test for CIN 1(5, 129, 0 and 191) andfor CIN 2/3 (47, 129, 4 and 191). Sensitivity, specificity, negative predictive value and positive predictive value in women with CIN 1 were 1.00, .60, 1.00 and .04 and with CIN 2/3 were .92, .60, .98 and .27, respectively.

CONCLUSION

This test is promisingfor early detection of cervical cancer given its high sensitivity. Understanding the biologic mechanisms underlying acetowhite changes necessitates further studies.

摘要

目的

确定醋酸试验（AAT）是否可作为早期检测宫颈癌的筛查试验。

研究设计

开展了一项基于医院的研究。纳入了1998年期间在杜兰戈州墨西哥社会保障局参加早期癌症检测项目的376名女性样本。在妇科检查期间进行醋酸试验。每位女性均接受了阴道镜检查和直接宫颈活检。

结果

活检显示，5名女性患有1级宫颈上皮内瘤变（CIN 1），51名患有2/3级宫颈上皮内瘤变。根据CIN 1（5、129、0和191）和CIN 2/3（47、129、4和191）的病理检查获得了四个值（真阳性、假阳性、假阴性和真阴性）。CIN 1女性的敏感性、特异性、阴性预测值和阳性预测值分别为1.00、0.60、1.00和0.04，CIN 2/3女性的分别为0.92、0.60、0.98和0.27。