Stewart K C, Patterson G A
Washington University School of Medicine, Department of Surgery, Barnes-Jewish Hospital, St. Louis, MO 63110, USA.
Am J Transplant. 2001 Sep;1(3):204-10. doi: 10.1034/j.1600-6143.2001.001003204.x.
Lung transplantation provides very good short- and acceptable long-term survival for patients with advanced lung disease. More widespread use of marginal and distant donors can be employed in selected recipients without compromising early or late results. Lack of suitable donor lungs and the development of BOS represent the biggest obstacles to more widespread application and long-term success of lung transplantation. The high rate of acute rejection and subsequent BOS clearly indicates that current immunosuppression strategies are inadequate. Further clinical and laboratory research into the pathogenesis of BOS will perhaps reveal new treatment options.
肺移植为晚期肺部疾病患者提供了很好的短期生存和可接受的长期生存。在特定受者中可以更广泛地使用边缘供体和远距离供体，而不会影响早期或晚期结果。缺乏合适的供肺以及闭塞性细支气管炎（BOS）的发生是肺移植更广泛应用和长期成功的最大障碍。急性排斥反应的高发生率及随后的BOS清楚地表明，目前的免疫抑制策略是不足的。对BOS发病机制的进一步临床和实验室研究可能会揭示新的治疗选择。
