青少年类风湿性关节炎的淀粉样变性——波兰和美国儿童的比较研究II.血清免疫球蛋白、κ和λ轻链及C3水平

The amyloidosis of juvenile rheumatoid arthritis - comparative studies in Polish and American children II. Serum immunoglobulins, kappa and lambda light chain and C3 levels.

作者信息

Filipowicz-Sosnowska A M, Baum J

出版信息

J Rheumatol. 1979 May-Jun;6(3):277-85.

Abstract

The concentration of serum IgG, IgM, IgA, IgD, IgE and complement C3 as well as Kappa and Lambda free and bound light chains were determined in sera from 21 amyloidotic Polish children with juvenile rheumatoid arthritis (JRA), Polish and American children with JRA, and control children from a Polish population. Comparable concentrations of IgG, IgM, IgA, IgE and C3 were found in amyloidotic children when compared to Polish JRA children with active polyarticular disease. However, the amyloidotic Polish children with JRA had significantly higher levels of IgG, IgM, IgA, IgE and complement C3 fraction when compared to American JRA children. The levels of IgA and IgE were significantly elevated in amyloidotic and Polish JRA populations when compared to American JRA patients. Free immunoglobulin light chains were not found in the sera of any of the children tested in this study. However, in the patients with amyloidosis, significantly diminished levels of bound Kappa and Lambda light chains were found.

摘要

测定了21名患青少年类风湿性关节炎（JRA）的波兰淀粉样变性儿童、患JRA的波兰儿童和美国儿童以及波兰普通对照儿童血清中IgG、IgM、IgA、IgD、IgE和补体C3的浓度，以及κ和λ游离轻链与结合轻链的水平。与患有活动性多关节疾病的波兰JRA儿童相比，淀粉样变性儿童的IgG、IgM、IgA、IgE和C3浓度相当。然而，与美国JRA儿童相比，患JRA且患有淀粉样变性的波兰儿童的IgG、IgM、IgA、IgE和补体C3水平显著更高。与美国JRA患者相比，淀粉样变性和波兰JRA人群中的IgA和IgE水平显著升高。在本研究检测的所有儿童血清中均未发现游离免疫球蛋白轻链。然而，在淀粉样变性患者中，发现结合κ和λ轻链水平显著降低。