Knott Verner, Mahoney Colleen, Kennedy Sidney, Evans Kenneth
Department of Psychiatry and Psychology, University of Ottawa/Royal Ottawa Hospital and Institute of Mental Health Research, Ottawa, ON, Canada.
J Affect Disord. 2002 May;69(1-3):241-9. doi: 10.1016/s0165-0327(01)00308-1.
Single dose administration of efficacious antidepressant agents elicit characteristic pharmaco-electroencephalographic (EEG) profiles in healthy volunteers but acute and chronic pharmaco-EEG profiling of antidepressant action in depressed patients has been relatively lacking. This study sought to examine the quantitative topographic EEGs of depressed patients in response to paroxetine treatment. Thirty male patients, meeting DSM-IV criteria for major depression, were examined before and after a single 20 mg dose. These, and an additional 40 patients, were also assessed following 6 weeks of treatment. Eyes-closed resting EEG, collected from 21 scalp sites, was spectrally analyzed to yield regional measures of absolute/relative power and mean frequency in delta, theta, alpha, beta and total spectrum frequency bands. Chronic treatment resulted in a significant reduction in scores on the Hamilton Rating Scale for Depression (HAM-D), with 80% of treatment completers exhibiting a >50% reduction in depression ratings at the end of the 6th week. Acute paroxetine did not alter EEG in patients but chronic treatment was associated with significant alterations as shown by diffuse decreases in alpha power and increases in slow (delta and theta) and anterior fast (beta) wave power, Mean theta and alpha (occipital) frequency were slowed while mean total frequency was accelerated at frontal sites and decreased at occipital sites. The chronic pharmaco-EEG response pattern reflects both sedating and activating actions in regional specific areas which are relevant to the pathophysiology and the pharmacotherapeutic treatment of depression.
在健康志愿者中，单剂量给予有效的抗抑郁药会引发特征性的药物脑电图（EEG）图谱，但在抑郁症患者中，对抗抑郁作用的急性和慢性药物脑电图分析相对较少。本研究旨在检查抑郁症患者在接受帕罗西汀治疗后的定量地形图脑电图。30名符合DSM-IV重度抑郁症标准的男性患者在单次服用20毫克剂量前后接受了检查。这些患者以及另外40名患者在接受6周治疗后也进行了评估。从21个头皮部位采集闭眼静息脑电图，进行频谱分析，以得出δ、θ、α、β和全频谱频段的绝对/相对功率和平均频率的区域测量值。慢性治疗导致汉密尔顿抑郁量表（HAM-D）评分显著降低，80%的完成治疗患者在第6周结束时抑郁评分降低超过50%。急性给予帕罗西汀对患者的脑电图没有影响，但慢性治疗与显著改变有关，表现为α波功率弥漫性降低，慢波（δ和θ）和前部快波（β）功率增加，平均θ波和α波（枕部）频率减慢，而平均全频率在额叶部位加快，在枕部部位降低。慢性药物脑电图反应模式反映了区域特定区域的镇静和激活作用，这与抑郁症的病理生理学和药物治疗相关。
