Grases Felix, Costa-Bauzá Antonia, Ramis Margarita, Montesinos Vicente, Conte Antonio
Laboratory of Renal Lithiasis Research, Faculty of Sciences, University of Balearic Islands, Ctra. Valldemossa Km. 7.5, 07071-Palma de Mallorca, Spain.
Clin Chim Acta. 2002 Aug;322(1-2):29-36. doi: 10.1016/s0009-8981(02)00063-3.
Classification of renal calculi with clear correlation with the main urinary etiological conditions has been previously established. However, such information is complex and difficult to adapt to clinical routine practice.
A simple classification of renal calculi based on their structure and composition is proposed and applied to 2500 renal calculi to achieve the percentage of each category. The urines of 700 individuals chosen randomly have been analyzed and the results compared with those obtained with 51 healthy subjects.
12.9% calculi corresponded to calcium oxalate monohydrate papillary calculi, 16.4% to calcium oxalate monohydrate unattached calculi, 33.8% to calcium oxalate dihydrate calculi, 11.2% calcium oxalate dihydrate/hydroxyapatite mixed calculi, 7.1% hydroxyapatite calculi, 4.1% struvite calculi, 0.6% brushite calculi, 8.2% uric acid calculi, 2.6% calcium oxalate/uric acid mixed calculi, 1.1% cystine calculi and 1.9% various infrequent calculi. Based on the corresponding urinary analytical studies, each kind of calculus is related with the more frequently associated urinary alterations.
An important aspect of this classification is the possibility to establish, by means of the correct study of the calculus, some of the main possible etiologic factors closely related to its formation.
先前已建立了与主要尿液病因状况有明确关联的肾结石分类。然而,此类信息复杂且难以应用于临床常规实践。
提出一种基于肾结石结构和成分的简单分类方法,并应用于2500颗肾结石以得出各类别的百分比。对随机选取的700名个体的尿液进行了分析,并将结果与51名健康受试者的结果进行比较。
12.9%的结石为一水合草酸钙乳头状结石,16.4%为一水合草酸钙游离结石,33.8%为二水合草酸钙结石,11.2%为二水合草酸钙/羟基磷灰石混合结石,7.1%为羟基磷灰石结石,4.1%为磷酸镁铵结石,0.6%为透钙磷石结石,8.2%为尿酸结石,2.6%为草酸钙/尿酸混合结石,1.1%为胱氨酸结石,1.9%为各种罕见结石。基于相应的尿液分析研究,每种结石都与更常见的尿液改变相关。
该分类的一个重要方面是通过对结石的正确研究,有可能确定与其形成密切相关的一些主要可能病因。