Dück K D
Z Gesamte Inn Med. 1975 Nov 15;30(22):727-30.
In two separated treatment groups of 18 and 30 hypertensive patients of the clinical degrees of severity II and III after insufficient propranolol monotherapy a combined propranolol/hydralazine or propranolol/hydrochlorothiazide treatment, respectively, was performed during several months. Under the combination therapy on average a clear increase of the effect of the beta-receptor blocker on the systolic as well as on the diastolic blood pressure is achieved. There were no essential side-effects. In accordance with modern opinions in the therapy of hypertension the combination of propranolol with a peripheral vasodilator and/or a salidiuretic should find a wide area of use, above all in hypertensive patients who are diastolically more difficult to be stabilised. The production of an adequate combination preparation is to be taken into consideration.
在两个分别由18名和30名临床严重程度为II级和III级的高血压患者组成的治疗组中，在普萘洛尔单一疗法效果不佳后，分别进行了几个月的普萘洛尔/肼屈嗪或普萘洛尔/氢氯噻嗪联合治疗。在联合治疗下，平均而言，β受体阻滞剂对收缩压和舒张压的效果明显增强。没有明显的副作用。根据现代高血压治疗观点，普萘洛尔与外周血管扩张剂和/或利尿剂的联合应用应具有广泛的用途，尤其是在舒张期血压更难稳定的高血压患者中。应考虑生产合适的复方制剂。
