δ-睡眠诱导肽在实验性急性胰腺炎中的药理作用

[Pharmacological efficacy of delta sleep-inducing peptide in experimental acute pancreatitis].

作者信息

Bondarenko T I, Kalmykova Iu A, Shustanova T A, Mikhaleva I I

机构信息

Department of Biochemistry and Microbiology, Rostov State University, ul. Bol'shaya Sadovaya 105, Rostov-on-Don, 344006 Russia.

出版信息

Eksp Klin Farmakol. 2002 Mar-Apr;65(2):44-8.

PMID:12109293

Abstract

The development of experimental acute pancreatitis (EOP) in rats is accompanied by (i) intensification of the lipid peroxidation (LPO) process and the accumulation of malonic dialdehyde (MDA, an LPO product) in the tissues of pancreas, liver, and kidney and in the blood serum, (ii) destabilization of membranes and reduction of the osmotic resistance of erythrocytes (ORE), (iii) increase in the concentration of extracorpuscular hemoglobin (ECH) and medium-molecular-weight molecules (MWM) in the blood serum, and intensification of protein autolysis in tissues. Preliminary triple intraperitoneal administration of a delta-sleep-inducing peptide (DSIP) in a dose of 12 micrograms/100 g body weight to the test rats with EOP stabilized LPO, improved the erythrocyte membrane structure, reduced the MDA level in tissues and blood serum, increased ORE, reduced the ECH and MWM level in the blood, and decreased the protein autolysis rate in tissues.

摘要

大鼠实验性急性胰腺炎（EOP）的发展伴随着以下情况：（i）胰腺、肝脏和肾脏组织以及血清中脂质过氧化（LPO）过程加剧，丙二醛（MDA，一种LPO产物）积累；（ii）膜稳定性下降，红细胞渗透抵抗力（ORE）降低；（iii）血清中细胞外血红蛋白（ECH）和中分子量分子（MWM）浓度增加，组织中蛋白质自溶加剧。预先以12微克/100克体重的剂量对患有EOP的实验大鼠进行三次腹腔内注射δ-睡眠诱导肽（DSIP），可稳定LPO，改善红细胞膜结构，降低组织和血清中的MDA水平，提高ORE，降低血液中的ECH和MWM水平，并降低组织中的蛋白质自溶率。