肾上腺髓质素可减轻雨蛙肽诱导的急性胰腺炎的严重程度。

Adrenomedullin reduces the severity of cerulein-induced acute pancreatitis.

作者信息

Onur Ozge Ecmel, Guneysel Ozlem, Akoglu Haldun, Denizbasi Arzu, Onur Ender

机构信息

Department of Emergency Medicine, Marmara University School of Medicine, Istanbul, Turkey.

出版信息

Peptides. 2007 Nov;28(11):2179-83. doi: 10.1016/j.peptides.2007.08.028. Epub 2007 Sep 5.

DOI:10.1016/j.peptides.2007.08.028

PMID:17928102

Abstract

We investigated the effect of Adrenomedullin (AM) on cerulein-induced acute pancreatitis in rats. AM treatment (100 ng/kg per rat, subcutaneous) after one hour of cerulein injection reduced the plasma amylase levels, pancreatic weight, pancreatic malondialdehyde (MDA) levels, and the severity of the lesions microscopically. These data suggest that AM has a protective effect on cerulein-induced acute pancreatitis. These could be due to anti-inflammatory properties of AM, inhibition of proinflammatory cytokine secretion, reducing the endothelial permeability increased by reactive oxygen species, endotoxins or cytokines.

摘要

我们研究了肾上腺髓质素（AM）对大鼠雨蛙肽诱导的急性胰腺炎的影响。在注射雨蛙肽1小时后进行AM治疗（每只大鼠100 ng/kg，皮下注射），可降低血浆淀粉酶水平、胰腺重量、胰腺丙二醛（MDA）水平，并在显微镜下减轻病变的严重程度。这些数据表明，AM对雨蛙肽诱导的急性胰腺炎具有保护作用。这可能归因于AM的抗炎特性、对促炎细胞因子分泌的抑制、降低由活性氧、内毒素或细胞因子引起的内皮通透性增加。