Mirotvorskaia G N
Zh Nevropatol Psikhiatr Im S S Korsakova. 1975;75(7):1057-64.
The author studied substances related to acetylcholine metabolism (acetylcholinesterase, non-specific acetylcholinesterase, SH, SS-groups, histidine, Ca) using histochemical methods. There was an increase in the intensity of reactions on SH-groups and Ca, and a rise in the staining degree on SS-groups and acetylcholinesterase in the subconvulsive phase of the stroke. These shifts were more significant in the brain stem. A generalization of convulsive strokes intensifies the given changes and causes an increase of the intensity of the reactions on histidine after the end of the stroke (after 1, 3, 6, 24, 48 and 72 hours). A normalization of the studied reactions happens at different times in the different brain areas and does not end completely even 72 hours following discontinuance of the convulsions. The author comes to the conclusion that the acetylcholine metabolism is inhibited during the covulsive stroke.
作者采用组织化学方法研究了与乙酰胆碱代谢相关的物质（乙酰胆碱酯酶、非特异性乙酰胆碱酯酶、SH、SS基团、组氨酸、钙）。在中风的亚惊厥期，SH基团和钙的反应强度增加，SS基团和乙酰胆碱酯酶的染色程度升高。这些变化在脑干中更为显著。惊厥性中风的泛化会加剧上述变化，并导致中风结束后（1、3、6、24、48和72小时后）组氨酸反应强度增加。所研究反应的正常化在不同脑区发生的时间不同，即使在惊厥停止72小时后也不会完全结束。作者得出结论，惊厥性中风期间乙酰胆碱代谢受到抑制。
