Ginestal da Cruz A, Correia J P, Menezes L
Acta Hepatogastroenterol (Stuttg). 1975 Dec;22(6):369-74.
Ethanol metabolism and its influence on serum lactate/pyruvate ratio was studied after intravenous infusion of ethanol in 17 patients: 4 controls, 5 alcoholics with cirrhosis, 4 non-alcoholic cirrhotics and 4 alcoholics without liver disease. All refrained from the use of alcohol and drugs 4 weeks prior to the experiment. After maximal ethanol blood levels were achieved at the end of the infusion, ethanol removal occurred at two different rates. This was probably due to the fact that different volumes of ethanol were distributed with time: a fast period (30 to 60 min) and a slow period (60 to 180 min). The rates of disappearence in the two periods were similar in all groups which suggests that liver cirrhosis, independent of clinical severity and/or chronic alcoholism with previous abstinence from alcohol, does not modify ethanol metabolic rates in the liver. The relation lactate/pyruvate doubled in all cases but it occurred within 30 minutes in the groups without liver disease and within 60 minutes in the cirrhotics. This could account for the decreased liability of cirrhotic patients to alcohol hypoglycemia.
对17例患者静脉输注乙醇后，研究了乙醇代谢及其对血清乳酸/丙酮酸比值的影响：4例对照者、5例肝硬化酗酒者、4例非酒精性肝硬化患者和4例无肝脏疾病的酗酒者。所有患者在实验前4周均戒酒及停用药物。在输注结束时达到最大乙醇血药浓度后，乙醇以两种不同速率消除。这可能是由于不同量的乙醇随时间分布：快速期（30至60分钟）和缓慢期（60至180分钟）。所有组在两个时期的消除速率相似，这表明肝硬化，无论临床严重程度如何和/或既往戒酒的慢性酒精中毒情况如何，均不改变肝脏中的乙醇代谢速率。所有病例中乳酸/丙酮酸比值均翻倍，但无肝脏疾病组在30分钟内发生，肝硬化患者在60分钟内发生。这可以解释肝硬化患者发生酒精性低血糖的可能性降低。
