未成熟髓样细胞与癌症相关的免疫抑制
Immature myeloid cells and cancer-associated immune suppression.
作者信息
Kusmartsev Sergei, Gabrilovich Dmitry I
机构信息
H. Lee Moffitt Cancer Center, University of South Florida, MRC-2, Room 2067, 12902 Magnolia Drive, Tampa, FL 33612, USA.
出版信息
Cancer Immunol Immunother. 2002 Aug;51(6):293-8. doi: 10.1007/s00262-002-0280-8. Epub 2002 Apr 24.
Abstract
Impaired balance between mature and immature myeloid cells is one of the hallmarks of cancer. In cancer patients as well as in mouse models there is increasing evidence that progressive tumor growth is associated with an accumulation of immature myeloid cells, monocytes/macrophages, and with a decreased number and function of dendritic cells (DC). This review examines recent findings on the contribution of immature myeloid cells (ImC) to cancer-induced immune suppression.
摘要
成熟与未成熟髓样细胞之间的平衡受损是癌症的标志之一。在癌症患者以及小鼠模型中，越来越多的证据表明，肿瘤的渐进性生长与未成熟髓样细胞、单核细胞/巨噬细胞的积累以及树突状细胞（DC）数量和功能的降低有关。这篇综述探讨了未成熟髓样细胞（ImC）对癌症诱导的免疫抑制作用的最新研究发现。
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