CD4+ T 细胞对髓源性抑制细胞抑制功能的调控。
Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells.
机构信息
Department of Internal Medicine, University of South Florida, Tampa, FL 33612, United States.
出版信息
Semin Cancer Biol. 2012 Aug;22(4):282-8. doi: 10.1016/j.semcancer.2012.01.010. Epub 2012 Jan 31.
Abstract
Myeloid derived suppressor cells play a critical role in T cell suppression in cancer. Here, we discuss the mechanisms of how MDSC suppress CD4(+) or CD8(+) T cells in an antigen dependent or non-dependent manner.
摘要
髓源性抑制细胞在癌症中 T 细胞抑制中发挥关键作用。在这里，我们讨论了 MDSC 以抗原依赖或非依赖的方式抑制 CD4(+)或 CD8(+)T 细胞的机制。
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2
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