关于非CPMG单次激发快速自旋回波序列在人脑扩散张量磁共振成像中的应用。
On the application of a non-CPMG single-shot fast spin-echo sequence to diffusion tensor MRI of the human brain.
作者信息
Bastin Mark E, Le Roux Patrick
机构信息
Department of Medical and Radiological Sciences (Medical Physics), University of Edinburgh, Western General Hospital, Edinburgh, UK.
出版信息
Magn Reson Med. 2002 Jul;48(1):6-14. doi: 10.1002/mrm.10214.
The strong sensitivity of Carr-Purcell-Meiboom-Gill (CPMG) fast spin-echo (FSE) sequences, such as rapid acquisition with relaxation enhancement (RARE), to the phase of the prepared transverse magnetization means that artifact-free single-shot diffusion-weighted images can currently only be obtained with a 30-50% reduction in the signal-to-noise ratio (SNR). However, this phase sensitivity and signal loss can be addressed in FSE sequences that use quadratic phase modulation of the radiofrequency (RF) refocusing pulses to generate a sustained train of stable echoes. Here the first application of such a non-CPMG single-shot FSE (ssFSE) sequence to diffusion tensor MR imaging (DT-MRI) of the human brain is described. This approach provides high SNR diffusion-weighted images that have little or no susceptibility to poor B(0) magnetic field homogeneity and the strong eddy currents typically present in DT-MRI experiments.
Carr-Purcell-Meiboom-Gill（CPMG）快速自旋回波（FSE）序列，如具有弛豫增强的快速采集（RARE），对准备好的横向磁化的相位具有很强的敏感性，这意味着目前仅能通过将信噪比（SNR）降低30 - 50%来获得无伪影的单次激发扩散加权图像。然而，在使用射频（RF）重聚焦脉冲的二次相位调制来生成持续稳定回波序列的FSE序列中，可以解决这种相位敏感性和信号损失问题。本文描述了这种非CPMG单次激发FSE（ssFSE）序列在人脑扩散张量磁共振成像（DT - MRI）中的首次应用。这种方法提供了高SNR的扩散加权图像，对B(0)磁场均匀性差以及DT - MRI实验中通常存在的强涡流几乎不敏感或不敏感。
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