使用非CPMG快速自旋回波序列对人类视神经进行扩散张量成像。

Diffusion tensor imaging of the human optic nerve using a non-CPMG fast spin echo sequence.

作者信息

Chabert Steren, Molko Nicolas, Cointepas Yann, Le Roux Patrick, Le Bihan Denis

机构信息

SHFJ/CEA, #4 Place du Général Leclerc, 91401 Orsay, France.

出版信息

J Magn Reson Imaging. 2005 Aug;22(2):307-10. doi: 10.1002/jmri.20383.

DOI:10.1002/jmri.20383

PMID:16028249

Abstract

PURPOSE

To investigate the diffusion tensor properties of the human optic nerve in vivo using a non-Carr-Purcell-Meiboom-Gill (CPMG) fast spin echo (FSE) sequence.

MATERIALS AND METHODS

This non-CPMG FSE sequence, which is based on a quadratic phase modulation of the refocusing pulses, allows diffusion measures to be acquired with full signal and without artifacts from geometric distortions due to magnetic field inhomogeneities, which are among the main problems encountered in the orbital area.

RESULTS

Good-quality images were obtained at a resolution of 0.94 x 0.94 x 3 mm. The mean diffusivity (MD) and fractional anisotropy (FA) were respectively 1.1 +/- 0.2 x 10(-3) mm(2)/second and 0.49 +/- 0.06, reflecting the optic nerve anisotropy.

CONCLUSION

This non-CPMG-FSE sequence provides reliable diffusion-weighted images of the human optic nerve. This approach could potentially improve the diagnosis and management of optic nerve diseases or compression, such as optic neuritis, orbit tumors, and muscle hypertrophy.

摘要