Park Kwan Ha, Park Jongmin, Koh Dongsoo, Lim Yoongho
Department of Marine Biomedical Sciences, Kunsan National University, Chonbuk, Korea.
Phytother Res. 2002 Jun;16(4):359-63. doi: 10.1002/ptr.903.
The separation and isolation of an extract of Bupleurum falcatum were performed based on antiallergic activities in preliminary studies with higher plants. The final active compound was identified as saikosaponin-A (SSA), a triterpenoid glycoside. SSA at more than 1 mg/kg (i.v.) significantly inhibited the passive cutaneous anaphylaxis reaction in rats in a dose-dependent manner, attaining a maximum inhibition of approximately 60% with 10 mg/kg. SSA at 3 and 10 mg/kg also suppressed asthmatic bronchoconstriction in sensitized guinea-pigs. SSA possesses a weak inhibitory activity on histamine-induced tracheal contraction in guinea-pigs and on histamine release induced by A-23187 in rat mast cells. These results indicate that SSA has an inhibitory activity against allergic asthma. This activity seems to derive from both antagonism of the histamine action and inhibition of allergic mediators. Additional mechanisms may also be involved.
在对高等植物的初步研究中，基于抗过敏活性对柴胡提取物进行了分离和提纯。最终确定的活性化合物为柴胡皂苷A（SSA），一种三萜糖苷。静脉注射剂量超过1mg/kg的SSA能以剂量依赖方式显著抑制大鼠被动皮肤过敏反应，10mg/kg时最大抑制率约为60%。3mg/kg和10mg/kg的SSA也能抑制致敏豚鼠的哮喘性支气管收缩。SSA对组胺诱导的豚鼠气管收缩以及A-23187诱导的大鼠肥大细胞组胺释放具有较弱的抑制活性。这些结果表明SSA具有抗过敏性哮喘的抑制活性。这种活性似乎源于组胺作用的拮抗和过敏介质的抑制。可能还涉及其他机制。
