柴胡皂苷 D 抑制选择素介导的细胞黏附。

Enviromental Agriculture Research Division, Gyeonggido Agricultural Reaearch and Extension Services(GARES), Hwaseong, Gyeonggi-do 445-784, Korea.

Bioindustial Process Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeollabuk-do 580-185, Korea.

Molecules. 2014 Dec 4;19(12):20340-9. doi: 10.3390/molecules191220340.

Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 µM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation.

从柴胡根的甲醇提取物中分离得到三种柴胡皂苷

柴胡皂苷 B3（1）；B4（2）；和 D（3）。这三种化合物中，化合物 3 对选择素（E、L 和 P）与 THP-1 细胞的相互作用具有抑制作用，IC50 值分别为 1.8、3.0 和 4.3µM。此外，化合物 3 的苷元结构 4 对 L-选择素介导的细胞黏附也表现出中等抑制活性。基于这些结果，我们怀疑从柴胡根中分离得到的化合物 3 可能是治疗炎症的一种有前途的治疗策略候选药物。