Hessel Amy C, Byers Robert M
Department of Head and Neck Surgery, Box 441, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
Head Neck. 2002 Jun;24(6):605-8. doi: 10.1002/hed.10077.
This retrospective study looks at the prognosis of desmoplastic melanoma of the lip, correlating it with the clinical course, treatment, and patterns of failure.
Twenty-two patients with desmoplastic melanoma of the lip were seen at the University of Texas M. D. Anderson Cancer Center from 1965 to 1998.
Three disease groups: (I) untreated tumor (3 patients), (II) excisional scar (10 patients), and (III) locoregional recurrence (9 patients). Group I had two cures and one failure. In group II six had no recurrences, and there were four failures. In group III, all patients failed. Ten patients (45%) had no evidence of disease, of which three (30%) had an initial misdiagnosis. Twelve patients (55%) died of disease or were living with disease, of which eight (67%) had an initial misdiagnosis.
Desmoplastic melanoma of the lip is often misdiagnosed and, therefore, inappropriately treated with multiple recurrences and poor prognosis. Accurate diagnosis and combined treatment may improve local control and survival.
本回顾性研究观察唇部促纤维增生性黑色素瘤的预后，并将其与临床病程、治疗及失败模式相关联。
1965年至1998年期间，德克萨斯大学MD安德森癌症中心共收治了22例唇部促纤维增生性黑色素瘤患者。
分为三个疾病组：（I）未经治疗的肿瘤（3例患者），（II）切除瘢痕（10例患者），以及（III）局部区域复发（9例患者）。I组有2例治愈，1例失败。II组中6例无复发，4例失败。III组所有患者均失败。10例患者（45%）无疾病证据，其中3例（30%）最初误诊。12例患者（55%）死于疾病或仍患有疾病，其中8例（67%）最初误诊。
唇部促纤维增生性黑色素瘤常被误诊，因此治疗不当，导致多次复发且预后不良。准确诊断和联合治疗可能改善局部控制和生存率。
