Department of Plastic, Reconstructive, and Aesthetic Surgery, Geneva University Hospitals, Geneva University, Geneva, Switzerland.
Department of Plastic, Reconstructive and Hand Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
In Vivo. 2023 May-Jun;37(3):1164-1172. doi: 10.21873/invivo.13191.
BACKGROUND/AIM: Cutaneous melanoma of the lip (LM) is a rare malignancy with a low overall survival (OS). Few studies exist in the literature to aid its diagnosis and treatment. The purpose of this study was to assess the different treatment modalities by collecting cases from a single database and to provide current information on the epidemiologic characteristics of cutaneous lip melanoma.
The SEER database was searched for demographic, clinical-pathological, and therapeutic characteristics. The Kaplan-Meier model was used to analyze the overall survival (OS) of the study population, and survival curves were modelled. Univariable analysis between subgroups was carried out using the log-rank test. Surgery was further assessed with a multivariable cox regression, where the surgical procedure was adjusted for Breslow thickness.
Patients aged 62.4 years on average, and 62.7% of them were males. A total of 386 melanomas of the cutaneous lip were identified. Mean OS was 155.1 months, median OS was 187 months, and 67.4% had localized disease.
LM has a poor prognosis with a 5-year OS of 75.2%. Surgery remains the mainstay of treatment, with less invasive surgical approaches yielding a comparable overall survival to surgery with greater margins.
背景/目的：唇部皮肤黑色素瘤（LM）是一种罕见的恶性肿瘤，总体存活率（OS）较低。文献中很少有研究可以辅助其诊断和治疗。本研究的目的是通过从单个数据库中收集病例来评估不同的治疗方式，并提供关于唇部皮肤黑色素瘤的流行病学特征的最新信息。
在 SEER 数据库中搜索了人口统计学、临床病理学和治疗特征。使用 Kaplan-Meier 模型分析研究人群的总生存率（OS），并构建生存曲线。使用对数秩检验对亚组之间进行单变量分析。对手术进一步进行多变量 Cox 回归分析，其中手术程序根据 Breslow 厚度进行调整。
患者平均年龄为 62.4 岁，其中 62.7%为男性。共确定了 386 例唇部皮肤黑色素瘤。平均 OS 为 155.1 个月，中位 OS 为 187 个月，67.4%为局限性疾病。
LM 预后不良，5 年 OS 为 75.2%。手术仍然是主要的治疗方法，采用侵袭性较小的手术方法与更大边缘的手术相比，总体生存率相当。
