Layfield Lester J, Gopez Evelyn V
Department of Pathology, Division of Anatomic Pathology, University of Utah School of Medicine, and ARUP Laboratories, Inc., Salt Lake City, Utah 84132, USA.
Diagn Cytopathol. 2002 Jun;26(6):398-403. doi: 10.1002/dc.10123.
Giant cell fibroblastoma is an uncommon soft tissue neoplasm occurring in childhood. It appears to be the juvenile form of dermatofibrosarcoma protuberans, with which it shares some histologic, cytogenetic, and immunohistochemical features. We report, to our knowledge, the second description of the cytologic features of giant cell fibroblastoma. The present case represents a recurrent lesion in the soft tissues of the scrotum of a 17-yr-old male. The aspirate produced moderately cellular smears containing mononuclear cells, usually lying singly, but occasionally forming clusters. The majority of the individual cells possessed scanty bipolar cytoplasm or were devoid of cytoplasm. The nuclei were bland, with small nucleoli. Nuclear membranes frequently contained notches, creases, or folds. Small fragments of metachromatic stroma were present in the background and were often associated with small aggregates of cells. Rare multinucleated giant cells containing bland oval or basillary-shaped nuclei were admixed with the spindle-cell component. Necrosis and mitotic figures were not a component of the smears. Surgical resection of the mass confirmed the diagnosis of giant cell fibroblastoma. We review the characteristic cytologic features of giant cell fibroblastoma and compare them with other soft tissue tumors in the differential diagnosis.
巨细胞成纤维细胞瘤是一种发生于儿童期的罕见软组织肿瘤。它似乎是隆突性皮肤纤维肉瘤的幼年型，二者具有一些组织学、细胞遗传学和免疫组化特征。据我们所知，我们报告了第二例关于巨细胞成纤维细胞瘤细胞学特征的描述。本例为一名17岁男性阴囊软组织的复发病变。穿刺涂片细胞中度丰富，含有单核细胞，通常单个存在，但偶尔形成簇状。大多数单个细胞胞质稀少呈双极状，或无胞质。细胞核形态温和，核仁小。核膜常可见切迹、皱折或折叠。背景中有少量异染性间质碎片，常与小细胞团块相关。罕见的含有温和椭圆形或基底状核的多核巨细胞与梭形细胞成分混合存在。坏死和有丝分裂象不是涂片的组成部分。肿物手术切除证实为巨细胞成纤维细胞瘤。我们回顾了巨细胞成纤维细胞瘤的特征性细胞学特征，并在鉴别诊断中将其与其他软组织肿瘤进行比较。
