de Walle H E K, de Jong-van den Berg L T W
EUROCAT-Registration, Department of Medical Genetics, University of Groningen, Groningen, The Netherlands.
Teratology. 2002 Jul;66(1):40-3. doi: 10.1002/tera.10078.
In 1993 all women of childbearing age in the Netherlands were advised to take a daily 0.5 mg folic acid pill to reduce the risk for neural tube defects. This study describes both recent and past awareness and use of folic acid supplements in relation to socio-economic status in the Northern Netherlands. The consequences of a recent report of the Dutch Health Council report will be discussed as well.
In the most recent cross-sectional study (November 2000), pregnant women filled out a questionnaire. Out of 473 women, 461 were willing to cooperate. The highest fulfilled level of education was taken as an indicator for socio-economic status.
Seventy-seven percent (n = 357) of the respondents had heard about folic acid before being pregnant. Sixty-three percent (n = 289) knew about the protective effect for NTDs and 33% (n = 151) knew the entire advised period. Sixty-one percent (n = 265) of the respondents used folic acid in some part of the advised period and 36% (n = 164) used it in the entire advised period. Higher educated women knew more about folic acid and used it significantly more often in the periconceptional period than lower educated women.
Because compliance to proper use of folic acid was poor, food fortification in the Netherlands must be seriously considered. The Dutch Health Council wants to limit the fortification of food products to those products that are especially aimed for women who wish to become pregnant. The fortification of specific products instead of staple foods is a missed chance to reduce NTDs and possibly other birth defects and cardiovascular defects as well.
1993年,荷兰建议所有育龄妇女每日服用0.5毫克叶酸片,以降低神经管缺陷的风险。本研究描述了荷兰北部近期和过去对叶酸补充剂的认知及使用情况与社会经济地位的关系。同时也将讨论荷兰卫生委员会近期一份报告的影响。
在最近的一项横断面研究(2000年11月)中,孕妇填写了一份问卷。在473名妇女中,461名愿意合作。将最高学历作为社会经济地位的指标。
77%(n = 357)的受访者在怀孕前听说过叶酸。63%(n = 289)知道其对神经管缺陷的预防作用,33%(n = 151)知道整个建议服用期。61%(n = 265)的受访者在建议服用期的某些阶段使用了叶酸,36%(n = 164)在整个建议服用期都使用了叶酸。高学历女性比低学历女性对叶酸了解更多,并且在受孕期间使用叶酸的频率明显更高。
由于正确使用叶酸的依从性较差,荷兰必须认真考虑食品强化问题。荷兰卫生委员会希望将食品强化限制在那些特别针对希望怀孕女性的产品上。强化特定产品而非主食是一个错失的降低神经管缺陷以及可能还有其他出生缺陷和心血管缺陷的机会。