来自绿南五味子的改性小檗碱和原小檗碱作为布氏锥虫的潜在抑制剂
Modified berberine and protoberberines from Enantia chlorantha as potential inhibitors of Trypanosoma brucei.
作者信息
Nyasse B, Nkwengoua E, Sondengam B, Denier C, Willson M
机构信息
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon.
出版信息
Pharmazie. 2002 Jun;57(6):358-61.
PMID:12116870
Abstract
Phytochemical study of the stem bark of Enantia chlorantha resulted in the isolation of two protoberberines 1 and 2. These alkaloids as well as commercially available berberine were modified chemically and tested in vitro against Typanosoma brucei proliferation as well as on three targeted glycolytic enzymes. The inhibitory activities observed were in the range of 20 microM (ED50 values).
摘要
对非洲绿柄桑茎皮进行植物化学研究，从中分离出两种原小檗碱1和2。对这些生物碱以及市售的黄连素进行化学修饰，并在体外针对布氏锥虫增殖以及三种靶向糖酵解酶进行测试。观察到的抑制活性范围为20微摩尔（半数有效剂量值）。
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