Sarbadhikary Paromita, George Blassan P
Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Johannesburg 2028, South Africa.
Plants (Basel). 2022 Sep 2;11(17):2293. doi: 10.3390/plants11172293.
Setten & P.J.Maas belongs to the Annonaceae family and is a multi-purpose medicinal plant, which has been extensively used for the traditional treatment option for malaria in western and central Africa. Its phytochemical composition is dominated particularly by various biologically active protoberberines and acetogenins. This review aims to provide a comprehensive review on the traditional uses, phytochemical profiles, and the toxicology of this plant from a myriad of available publications. Even after its tremendous applications against several different human ailments, this plant has been underestimated for its anticancer potential. Herein, based on the phytochemical composition, we discuss the probable mode of mechanism for its antiproliferative activity, which highlights its importance for cytotoxicity screenings against cancer cells. Additionally, this article discusses several research questions and suggests the future directions of its applications in medicinal plant-based anticancer research.
塞滕番荔枝（Setten & P.J.Maas）属于番荔枝科，是一种多用途药用植物，在西非和中非被广泛用作疟疾的传统治疗选择。其植物化学成分尤其以各种具有生物活性的原小檗碱和番荔枝内酯为主。本综述旨在从大量现有出版物中对该植物的传统用途、植物化学概况和毒理学进行全面综述。尽管它在对抗多种不同人类疾病方面有巨大应用，但这种植物的抗癌潜力一直被低估。在此，基于其植物化学成分，我们讨论了其抗增殖活性的可能作用机制，这凸显了它在针对癌细胞的细胞毒性筛选中的重要性。此外，本文讨论了几个研究问题，并提出了其在基于药用植物的抗癌研究中的未来应用方向。
