具有抗溃疡分枝杆菌活性的药用植物研究进展
Update on Medicinal Plants with Potency on Mycobacterium ulcerans.
作者信息
Tsouh Fokou Patrick Valere, Nyarko Alexander Kwadwo, Appiah-Opong Regina, Tchokouaha Yamthe Lauve Rachel, Ofosuhene Mark, Boyom Fabrice Fekam
机构信息
Clinical Pathology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O. Box LG 581, Accra, Ghana; Antimicrobial Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé 1, P.O. 812, Yaoundé, Cameroon.
Clinical Pathology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O. Box LG 581, Accra, Ghana; Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, P.O. Box LG 43, Legon, Ghana.
出版信息
Biomed Res Int. 2015;2015:917086. doi: 10.1155/2015/917086. Epub 2015 Dec 8.
Mycobacterium ulcerans disease has been a serious threat for people living in rural remote areas. Due to poverty or availability of traditional medicine these populations rely on herbal remedies. Currently, data on the anti-Mycobacterium ulcerans activity of plants, so far considered community-based knowledge, have been scientifically confirmed, concomitantly with some medicinal plants used to treat infectious diseases in general. Products derived from plants usually responsible for the biological properties may potentially control Mycobacterium ulcerans disease; numerous studies have aimed to describe the chemical composition of these plant antimicrobials. Thus, the present work provides the first compilation of medicinal plants that demonstrated inhibitory potential on Mycobacterium ulcerans. This work shows that the natural products represent potential alternatives to standard therapies for use as curative medicine for Mycobacterium ulcerans disease.
溃疡分枝杆菌病一直对生活在农村偏远地区的人们构成严重威胁。由于贫困或传统药物的可得性，这些人群依赖草药疗法。目前，关于植物抗溃疡分枝杆菌活性的数据，迄今被认为是基于社区的知识，已得到科学证实，同时还有一些通常用于治疗传染病的药用植物。通常具有生物学特性的植物衍生产品可能有潜力控制溃疡分枝杆菌病；许多研究旨在描述这些植物抗菌剂的化学成分。因此，本研究首次汇编了对溃疡分枝杆菌具有抑制潜力的药用植物。这项研究表明，天然产物代表了作为溃疡分枝杆菌病治疗药物的标准疗法的潜在替代品。
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