Peitsch Manuel C
Novartis Pharma AG, WKL-490.4.04, 4002 Basel, Switzerland Swiss Institute of Bioinformatics, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.
Bioinformatics. 2002 Jul;18(7):934-8. doi: 10.1093/bioinformatics/18.7.934.
Protein models can be of great assistance in functional genomics, as they provide the structural insights often necessary to understand protein function. Although comparative modelling is far from yielding perfect structures, this is still the most reliable method and the quality of the predictions is now well understood. Models can be classified according to their correctness and accuracy, which will impact their applicability and usefulness in functional genomics and a variety of situations.
蛋白质模型在功能基因组学中能提供很大帮助，因为它们常常能提供理解蛋白质功能所需的结构信息。尽管比较建模远不能产生完美的结构，但这仍然是最可靠的方法，并且现在对预测质量已有很好的理解。模型可以根据其正确性和准确性进行分类，这将影响它们在功能基因组学及各种情况下的适用性和实用性。
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