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超过40周进行胎膜剥离是否会减少正式引产的必要性?

Does sweeping of membranes beyond 40 weeks reduce the need for formal induction of labour?

作者信息

Wong S F, Hui S K, Choi H, Ho L C

机构信息

Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Hong Kong, SAR, People's Republic of China.

出版信息

BJOG. 2002 Jun;109(6):632-6. doi: 10.1111/j.1471-0528.2002.01193.x.

Abstract

OBJECTIVE

To assess the efficacy of sweeping of membranes beyond 40 weeks of gestation in reducing the incidence of induction of labour, when induction was planned at 42 weeks.

DESIGN

Prospective randomised controlled trial.

SETTING

A regional obstetric unit in Hong Kong.

POPULATION AND METHODS

A total of 120 women with certain gestational age, determined by early pregnancy ultrasound scan, were recruited from 1st July, 1998 to 31st December, 1999. Sixty women were randomly allocated to sweeping of membranes and the other 60 women acted as control. The satisfaction for women allocated to sweeping of membranes was assessed by a questionnaire after the procedure. The two groups were assessed on intention-to-treat basis.

MAIN OUTCOME MEASURES

The incidence of formal induction of labour was compared between the two groups. Possible complications of sweeping of membranes such as rupture of membranes, intrapartum infection, postpartum infection, and neonatal infection were also assessed. Maternal and perinatal outcomes were also assessed.

RESULTS

The recruitment to delivery interval was significantly shorter among women who had sweeping of membranes (3.2 versus 4.2 days, P < 0.05). The incidence of induction of labour was comparable (35.5% versus 38%, RR 0.91, 95% CI 0.57 - 1.46). The incidences of caesarean section and assisted vaginal delivery were comparable. The incidences of premature rupture of membranes, intrapartum, and postpartum infection were comparable. The perinatal outcomes were also comparable between the two groups. Up to 70% of women found that this procedure was associated with significant discomfort. One third of these women complained of significant pain.

CONCLUSIONS

Sweeping of membranes beyond 40 weeks does not reduce the need for formal induction of labour at 42 weeks. Although it is safe, the majority of women felt uncomfortable during the procedure.

摘要

目的

评估妊娠40周后行胎膜剥离术对降低计划在42周引产时引产发生率的效果。

设计

前瞻性随机对照试验。

地点

香港某地区产科单位。

研究对象与方法

1998年7月1日至1999年12月31日,共招募了120名经孕早期超声扫描确定孕周的妇女。60名妇女被随机分配至胎膜剥离组,另外60名妇女作为对照组。胎膜剥离组妇女术后通过问卷调查评估满意度。两组均按意向性分析原则进行评估。

主要观察指标

比较两组正式引产的发生率。还评估了胎膜剥离术可能的并发症,如胎膜破裂、产时感染、产后感染和新生儿感染。同时评估母婴结局。

结果

胎膜剥离组妇女从招募到分娩的间隔时间显著缩短(3.2天对4.2天,P<0.05)。引产发生率相当(35.5%对38%,相对危险度0.91,95%可信区间0.57 - 1.46)。剖宫产和阴道助产的发生率相当。胎膜早破、产时及产后感染的发生率相当。两组围产期结局也相当。高达70%的妇女发现该操作会带来明显不适。其中三分之一的妇女抱怨疼痛剧烈。

结论

妊娠40周后行胎膜剥离术并不能减少42周时正式引产的需求。虽然该操作安全,但大多数妇女在操作过程中感到不适。

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