Iurenev P N, Sergeiuk E M, Samoĭlova L N, Kakurina A V
Antibiotiki. 1975 Oct;20(10):936-41.
Analysis of 302 side effects of antibiotic theraphy is presented. The side effects were studied comparatively as dependent on the antibiotic group. Dependence of the toxic and toxicoallergic reactions to the antibiotics on the antibiotic blood levels were noted. Previous sensitization resulted in more frequent and earlier side effects. The analysis and clinical observations showed that antibiotic therapy should take into account the results of the laboratory tests, i.e. examination of the kidney functional state, antibiotic levels in the blood and urine, tolerance of the drug by the patient.
本文呈现了对抗生素治疗302例副作用的分析。根据抗生素类别对副作用进行了比较研究。注意到抗生素的毒性和毒过敏反应与抗生素血药浓度有关。先前的致敏反应导致更频繁、更早出现副作用。分析和临床观察表明,抗生素治疗应考虑实验室检查结果,即肾功能状态检查、血液和尿液中的抗生素水平以及患者对药物的耐受性。