Chen Dexiang, Payne Lendon G
PowderJect Vaccines, Inc., Madison, WI 53711, USA.
Cell Res. 2002 Jun;12(2):97-104. doi: 10.1038/sj.cr.7290115.
Immune reactions to foreign or self-antigens lead to protective immunity and, sometimes, immune disorders such as allergies and autoimmune diseases. Antigen presenting cells (APC) including epidermal Langerhans cells (LCs) play an important role in the course and outcome of the immune reactions. Epidermal powder immunization (EPI) is a technology that offers a tool to manipulate the LCs and the potential to harness the immune reactions towards prevention and treatment of infectious diseases and immune disorders.
对外来或自身抗原的免疫反应会产生保护性免疫，有时也会导致免疫紊乱，如过敏和自身免疫性疾病。包括表皮朗格汉斯细胞（LCs）在内的抗原呈递细胞（APC）在免疫反应的过程和结果中起着重要作用。表皮粉末免疫（EPI）是一种技术，它提供了一种操纵LCs的工具，并且有利用免疫反应来预防和治疗传染病及免疫紊乱的潜力。
