Chen Dexiang, Maa Yuh-Fun, Haynes Joel R
PowderJect Vaccines Inc., Madison, WI 53711, USA.
Expert Rev Vaccines. 2002 Oct;1(3):265-76. doi: 10.1586/14760584.1.3.265.
Due to the presence of a network of antigen-presenting cells and other cells with innate and adaptive immune functions, the skin is both a sensitive immune organ and a practical target site for vaccine administration. A handful of needle-free immunization technologies have emerged in recent years that aim to take advantage of these characteristics. Skin delivery technologies provide potentially safer alternatives to needle injection and promises increased efficacy in the prevention and/or therapy of infectious diseases, allergic disorders and cancer. In this review, we will cover advances in needle-free skin vaccination technologies and their potential applications to disease prevention and therapy. Emphasis will be placed on epidermal powder immunization and particle-mediated ('gene gun') DNA immunization, which use similar mechanical devices to deliver protein and DNA vaccines, respectively, into the viable epidermis.
由于存在抗原呈递细胞网络以及其他具有先天和适应性免疫功能的细胞，皮肤既是一个敏感的免疫器官，也是疫苗接种的实际靶位点。近年来出现了一些无针免疫技术，旨在利用这些特性。皮肤给药技术为注射针头提供了潜在更安全的替代方法，并有望提高在预防和/或治疗传染病、过敏性疾病及癌症方面的疗效。在本综述中，我们将阐述无针皮肤疫苗接种技术的进展及其在疾病预防和治疗中的潜在应用。重点将放在表皮粉末免疫和粒子介导（“基因枪”）DNA免疫上，它们分别使用类似的机械装置将蛋白质和DNA疫苗递送至活表皮中。
