Nicholson R, Calamera J C
Int J Fertil. 1976;21(3):176-80.
Diesterase activity was studied in human uterine secretions of normal women and in those under treatment for sterility or contraception. Endometrial secretions were obtained from 78 patients and the material divided into four groups: normal women, under different estrogens; with D-Norgestrel treatment (daily and post-coital) and patients with IUD Lippes D. The mean concentration of free choline delivered by the GPC diesterase in the normal group was 777 +/- 128 mug/ml (SD 286). Under hormonal treatment an increase of diesterase activity was observed. D-Norgestrel post-coital produced a fall of the enzymatic activity between 180 to 420 minutes. The uninterrupted use of D-Norgestrel (30 gammas daily) produced a loss of diesterase activity in 80% of cases studied. The use of IUD (Lippes D) did not modify the enzymatic activity in this group.
对正常女性以及接受不育或避孕治疗女性的人子宫分泌物中的二酯酶活性进行了研究。从78名患者获取子宫内膜分泌物，并将材料分为四组：正常女性、接受不同雌激素治疗的女性、接受炔诺孕酮治疗（每日及性交后）的女性以及使用利普斯D型宫内节育器的患者。正常组中甘油磷酸胆碱二酯酶释放的游离胆碱平均浓度为777±128微克/毫升（标准差286）。在激素治疗下，观察到二酯酶活性增加。性交后使用炔诺孕酮会使酶活性在180至420分钟之间下降。持续使用炔诺孕酮（每日30微克）在80%的研究病例中导致二酯酶活性丧失。使用宫内节育器（利普斯D型）未改变该组中的酶活性。
