Takahashi Y, Ruhl S, Yoon J-W, Sandberg A L, Cisar J O
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Oral Microbiol Immunol. 2002 Aug;17(4):257-62. doi: 10.1034/j.1399-302x.2002.170409.x.
The binding of 10 viridans group streptococci to sialic acid-, galactose (Gal)- and N-acetylgalactosamine (GalNAc)-containing receptors was defined by analysis of the interactions between these bacteria and structurally defined glycoconjugates, host cells and other streptococci. All interactions with sialic acid-containing receptors were Ca(2+)-independent as they were not affected by ethyleneglycoltetraacetic acid (EGTA), whereas all interactions with Gal- and GalNAc-containing receptors were Ca(2+)-dependent. Recognition of sialic acid-, Gal- and GalNAc-containing receptors varied widely among the strains examined, in a manner consistent with the association of each of the three lectin-like activities with a different bacterial cell surface component.
通过分析10株草绿色链球菌与结构明确的糖缀合物、宿主细胞及其他链球菌之间的相互作用，确定了这些细菌与含唾液酸、半乳糖（Gal）和N-乙酰半乳糖胺（GalNAc）的受体的结合情况。与含唾液酸受体的所有相互作用均不依赖于Ca(2+)，因为它们不受乙二醇四乙酸（EGTA）的影响，而与含Gal和GalNAc受体的所有相互作用均依赖于Ca(2+)。在所检测的菌株中，对含唾液酸、Gal和GalNAc受体的识别差异很大，其方式与三种凝集素样活性中的每一种与不同细菌细胞表面成分的关联一致。
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